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Index > Protein center > OAS2(Gene name) > Human
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  • OAS2 (Gene name),
  • 2'-5'-oligoadenylate synthase 2 (Protein name ),  OAS2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    OAS2;
    Protein name:
    2'-5'-oligoadenylate synthase 2((2-5')oligo(A) synthase 2;2-5A synthase 2);
    Alternative:
    p69 OAS / p71 OAS(p69OAS / p71OAS);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    May play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis.
    Subcellular Location:
    Mitochondrion Nucleus Microsome Endoplasmic reticulum Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.
    Protein Attributes:
    Sequence length:
    719
    Sequence:
    50:
    MGNGESQLSS | VPAQKLGWFI | QEYLKPYEEC | QTLIDEMVNT | ICDVLQEPEQ | 
    100:
    FPLVQGVAIG | GSYGRKTVLR | GNSDGTLVLF | FSDLKQFQDQ | KRSQRDILDK | 
    150:
    TGDKLKFCLF | TKWLKNNFEI | QKSLDGFTIQ | VFTKNQRISF | EVLAAFNALS | 
    200:
    LNDNPSPWIY | RELKRSLDKT | NASPGEFAVC | FTELQQKFFD | NRPGKLKDLI | 
    250:
    LLIKHWHQQC | QKKIKDLPSL | SPYALELLTV | YAWEQGCRKD | NFDIAEGVRT | 
    300:
    VLELIKCQEK | LCIYWMVNYN | FEDETIRNIL | LHQLQSARPV | ILDPVDPTNN | 
    350:
    VSGDKICWQW | LKKEAQTWLT | SPNLDNELPA | PSWNVLPAPL | FTTPGHLLDK | 
    400:
    FIKEFLQPNK | CFLEQIDSAV | NIIRTFLKEN | CFRQSTAKIQ | IVRGGSTAKG | 
    450:
    TALKTGSDAD | LVVFHNSLKS | YTSQKNERHK | IVKEIHEQLK | AFWREKEEEL | 
    500:
    EVSFEPPKWK | APRVLSFSLK | SKVLNESVSF | DVLPAFNALG | QLSSGSTPSP | 
    550:
    EVYAGLIDLY | KSSDLPGGEF | STCFTVLQRN | FIRSRPTKLK | DLIRLVKHWY | 
    600:
    KECERKLKPK | GSLPPKYALE | LLTIYAWEQG | SGVPDFDTAE | GFRTVLELVT | 
    650:
    QYQQLCIFWK | VNYNFEDETV | RKFLLSQLQK | TRPVILDPAE | PTGDVGGGDR | 
    700:
    WCWHLLAKEA | KEWLSSPCFK | DGTGNPIPPW | KVPTMQTPGS | CGARIHPIVN | 
    719:
    EMFSSRSHRI | LNNNSKRNF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    KEGG:
    String:
    Pfam:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human (2-5')oligo(A) synthase 2
    Cat.:
    E0722m
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human (2-5')oligo(A) synthase 2
    Cat.:
    E0722h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human (2-5')oligo(A) synthase 2
    Cat.:
    E0722b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human (2-5')oligo(A) synthase 2
    Cat.:
    E0722r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human (2-5')oligo(A) synthase 2
    Cat.:
    U0722r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human (2-5')oligo(A) synthase 2
    Cat.:
    U0722m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human (2-5')oligo(A) synthase 2
    Cat.:
    U0722h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human (2-5')oligo(A) synthase 2
    Cat.:
    U0722b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human (2-5')oligo(A) synthase 2
    Cat.:
    P0722Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human (2-5')oligo(A) synthase 2
    Polyclonal Antibody for Human (2-5')oligo(A) synthase 2
    Cat.:
    P0722Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human (2-5')oligo(A) synthase 2
    Cat.:
    P0722Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human (2-5')oligo(A) synthase 2
    Monoclonal Antibody for Human (2-5')oligo(A) synthase 2
    Monoclonal Antibody for Human (2-5')oligo(A) synthase 2
    Monoclonal Antibody for Human (2-5')oligo(A) synthase 2
    Protein for Human (2-5')oligo(A) synthase 2
    Protein for Human (2-5')oligo(A) synthase 2
    Protein for Human (2-5')oligo(A) synthase 2
    Protein for Human (2-5')oligo(A) synthase 2

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    Precision
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    Linearity
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    References
    1. 1.
      "The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains."
      Marie I. , Hovanessian A.G.
      J. Biol. Chem.267:9933-9939(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS P69 AND P71)
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM P69)
      tissue: Trachea.
    3. 3.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS P69 AND 3)
      tissue: Blood.
      tissue: Uterus.
    6. 6.
      "Identification of the substrate-binding sites of 2'-5'-oligoadenylate synthetase."
      Sarkar S.N. , Miyagi M. , Crabb J.W. , Sen G.C.
      J. Biol. Chem.277:24321-24330(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 420-425 AND 539-547;IDENTIFICATION BY MASS SPECTROMETRY;BIOPHYSICOCHEMICAL PROPERTIES;MUTAGENESIS OF TYR-421; ARG-544 AND LYS-547
    7. 7.
      "Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon."
      Marie I. , Svab J. , Robert N. , Galabru J. , Hovanessian A.G.
      J. Biol. Chem.265:18601-18607(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MYRISTOYLATION AT GLY-2;SUBCELLULAR LOCATION
    8. 8.
      "Enzymatic characteristics of recombinant medium isozyme of 2'-5' oligoadenylate synthetase."
      Sarkar S.N. , Bandyopadhyay S. , Ghosh A. , Sen G.C.
      J. Biol. Chem.274:1848-1855(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES;SUBUNIT;ENZYME REGULATION;GLYCOSYLATION;MYRISTOYLATION;MUTAGENESIS OF GLY-2
    9. 9.
      "The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases."
      Sarkar S.N. , Ghosh A. , Wang H.W. , Sung S.S. , Sen G.C.
      J. Biol. Chem.274:25535-25542(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;BIOPHYSICOCHEMICAL PROPERTIES;MUTAGENESIS OF ASP-408; ASP-410; ASP-481; CYS-668; PHE-669 AND LYS-670
    10. 10.
      "The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation."
      Hovanessian A.G. , Justesen J.
      Biochimie89:779-788(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    11. 11.
      "Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection."
      Lin R.J. , Yu H.P. , Chang B.L. , Tang W.C. , Liao C.L. , Lin Y.L.
      J. Immunol.183:8035-8043(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    12. 12.
      "Evolution of the 2'-5'-oligoadenylate synthetase family in eukaryotes and bacteria."
      Kjaer K.H. , Poulsen J.B. , Reintamm T. , Saby E. , Martensen P.M. , Kelve M. , Justesen J.
      J. Mol. Evol.69:612-624(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    13. 13.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-378;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities."
      Kristiansen H. , Gad H.H. , Eskildsen-Larsen S. , Despres P. , Hartmann R.
      J. Interferon Cytokine Res.31:41-47(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
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